secondary metabolites and biological activities of talaromyces sp. lgt-2, an endophytic fungus from tripterygium wilfordii

نویسندگان

qiuhong zhao lanzhou university of technology

zhongduo yang lanzhou university of technology

yonggang wang lanzhou university of technology

zongmei shu lanzhou university of technology

چکیده

abstract in the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from talaromyces sp. lgt-2, an endophytic fungus from tripterygium wilfordi. their structures were determined based on nmr and esi-ms spectral data, as well as comparing with previous literature data. this is the first report of the isolation of alkaloids (1-9) from talaromyces genus. in the next step, all compounds were screened for their anti-monoamine oxidase, anti-acetylcholinesterase, antibacterial and antitumor activities. compound 11 showed moderate anti-monoamine oxidase activity with ic50 value of 61 μm; compounds 3, 4, 8 showed weaker anti-acetylcholinesterase activity; compounds 1, 3, 4, 7, 8, 9 showed moderate antibacterial activities; compounds 7, 8, 9 showed cytotoxicity against b16 cancer cell line with inhibitory rate of 86%, 82%, 78%, respectively, at the concentration of 500 μg/ml.

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منابع مشابه

Secondary metabolites and biological activities of Talaromyces sp. LGT-2, an endophytic fungus from Tripterygium wilfordii

Abstract In the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from Talaromyces sp. LGT-2, an endophytic fungus from Tripterygium wilfordi. Their structures were determined based on NMR and ESI-MS spectral data, as well as comparing with previous literature data. This is the first report of the isolation ...

متن کامل

Secondary metabolites and biological activities of Talaromyces sp. LGT-2, an endophytic fungus from Tripterygium wilfordii

Abstract In the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from Talaromyces sp. LGT-2, an endophytic fungus from Tripterygium wilfordi. Their structures were determined based on NMR and ESI-MS spectral data, as well as comparing with previous literature data. This is the first report of the isolation ...

متن کامل

Secondary Metabolites and Biological Activities of Talaromyces sp. LGT-2, an Endophytic Fungus from Tripterygium Wilfordii

In the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from Talaromyces sp. LGT-2, an endophytic fungus from Tripterygium wilfordi. Their structures were determined based on NMR and ESI-MS spectral data, as well as comparing previous literature data. This is the first report of the isolation of alkaloids (...

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Chemical Composition and Biological Activities of Endophytic Fungus Talaromyces Wortmannii LGT-4, Cultured in CYM Medium

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عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۱۵، شماره ۳، صفحات ۴۵۳-۴۵۷

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